'House,' Fox (2004-2012)
This medical drama bows Monday after an eight-season run, following genius diagnostician Dr. Gregory House (multi-Emmy nominee Hugh Laurie) and his team of doctors as they solve impossible cases. House skyrocketed Olivia Wilde (Thirteen) into the limelight, and brought attention to Lisa Edelstein (Cuddy), Omar Epps (Foreman), Kal Penn (Kutner) and other cast members.
Why it’s leaving -- and what its legacy may be: Ratings have fallen, and the executive producers said they chose to end House on a high note, keeping the show’s integrity intact to the very end. House will be remembered as a show that pushed ethical boundaries and developed mesmerizing, layered characters.